CAS 718-08-1 BMK Chemical Syntheses Material Intermediates Liquid Form Oil

Product parameters

Product Name:	Benzenebutanoic acid,b-oxo-,ethyl ester
CAS :	718-08-1
Synonyms:	3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER;3-keto-4-phenyl-butyric acid ethyl ester;ethyl 3-oxo-4-phenylbutanoate;ethyl 3-oxo-4-phenyl-butanoate;4-Phenyl-3-oxobutanoic acid ethyl ester;Ethyl 4-phenylacetoacetate
Category:	Heterocyclic Organic Compound

Molecular Formula:	C12H14O3
Molecular Weight:	260.24
Density:	1.091
Boiling Point:	290°C
Flash Point:	124℃
Category:	Heterocyclic Organic Compound
Canonical SMILES:	CCOC(=O)CC(=O)CC1=CC=CC=C1

Physical: properties:	Diethyl(phenylacetyl)malonate has a boiling point of 290℃ Its density is predicted to be 1.091.
Uses:	A useful synthetic intermediate, often used in the preparation of anti-prion compounds and gene expression inhibitors
Preparation:	(1) Ethyl acetoacetate and methylene chloride of phenylacetyl chloride were prepared into a mixture in a certain proportion, and then the mixture and sulfone chloride were continuously injected into the micro-channel reactor with a metering pump at a certain proportion of flow, and the discharge temperature of the reactor was controlled at 5 ~ 10℃. (2) Under atmospheric pressure, the reaction liquid after washing is slowly heated. When the bottom temperature of the kettle reaches 55 ° C, dichloromethane begins to steam out, and stops heating until the kettle temperature reaches 100 ° C, and the distilled solvent is collected and cooled. (3) Under the vacuum degree of -0.1MPa, the recovered solvent is reduced pressure rectification and slowly heated. When the kettle temperature reaches 85 ~ 90℃, finished products begin to steam out. When the kettle temperature rises to 120℃, the heating is stopped and the vacuum pump is turned off to obtain qualified finished products 3-oxy-4-phenyl-ethyl butyrate.