NAD+ is a coenzyme of dehydrogenase, such as alcohol dehydrogenase (ADH), used to oxidize ethanol. It plays an irreplaceable role in glycolysis, gluconeogenesis, tricarboxylic acid cycle and respiratory chain.
NAD+ has several important roles in metabolism. It acts as a coenzyme in the redox reaction as the posterior of the ADP-ribose moiety in the ADP-ribosylation reaction, as the precursor of the second messenger molecule cyclic ADP-ribose, and as the substrate of bacterial DNA ligase and group Known as a silent enzyme, it uses NAD+ to remove acetyl groups from proteins. In addition to metabolic functions, NAD+ appears as adenine nucleotides and can release cells spontaneously through regulatory mechanisms, so it can have important extracellular effects.
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